Pitt Receives NIH Grants to Study Health Effects of Chemical Exposures Following the East Palestine Train Derailment

April 2, 2024

Pitt researchers have received a pair of two-year grants from the National Institutes of Health to support studies on the health effects of environmental contamination resulting from the train derailment that spilled hazardous materials into the local communities in East Palestine, Ohio, in February 2023.

The grants, totaling nearly $1 million, were awarded through a National Institute of Environmental Health Sciences program known as Time Sensitive Research Opportunities in Environmental Health, which supports research to characterize initial environmental exposures and collect biospecimens and other data—in this case, from residents potentially affected by the train derailment.

“After an immediate threat of a disaster is neutralized, there is still much work to be done to meet the public health needs of the community,” said Maureen Lichtveld (left in photo), dean and Jonas Salk Professor of Population Health, School of Public Health. “We have built a transdisciplinary team of experts in environmental health, disaster preparedness, clinical toxicology and psychology to this end, and we are committed to embedding a community-engaged approach in our work.”

Juliane Beier (right in photo), assistant professor of medicine, School of Medicine, and of environmental and occupational health, School of Public Health, and Lichtveld are principal investigators of the first grant, “East Palestine Community-Engaged Environmental Exposure, Health Data, and Biospecimen Bank.” In response to vinyl chloride and other chemicals leaking into the environment and, potentially, into area homes, Pitt researchers will partner with community advisors and area citizen-scientists to collect air and water samples from inside about 100 residences in areas surrounding the derailment site. They will also collaborate in collecting biospecimens, as well as data on the health outcomes of 300 volunteer participants.

Investigators will evaluate these biospecimens to detect early signs of liver dysfunction, said Lichtveld, explaining that vinyl chloride is a known liver carcinogen.

Peng Gao (middle in photo), assistant professor of environmental and occupational health, School of Public Health, and of civil and environmental engineering, Swanson School of Engineering, is principal investigator of the second research grant, “Profiling the Post-Accident Exposome in East Palestine.” This team will collect soil, water and sediment samples to characterize the extent of the chemical contamination and the ongoing environmental impact on the region.

Read more from the news release.